The SUR2A Antibody: HRP from MyBioSource.com is a Mouse Monoclonal antibody to ABC37, ABCC9, SUR2B, and SUR2A. This antibody recognizes Mouse, and Rat antigen. The SUR2A Antibody: HRP has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
Background Info: Detects ~120kDa. Does not crossreact with SUR2B.
Scientific Background: Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four K ir6.x and four SUR subunits form an ion conducting channel commonly referred to as the K ATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir 6.x potassium channel. Hence the K ATP channel monitors the energy balance within the cell (2)